Skip second minimization if trailblaze has run
@@ -3080,6 +3080,9 @@ class ExperimentBuilder(object):
# If this is SAMS, just use the sampler state associated
# to the initial thermodynamic state.
sampler_state = sampler_state[0]
+ # Also, these states have been already minimized so we
+ # can skip a second minimization.
+ phase_opts['minimize'] = False
# Identify system components. There is a ligand only in the complex phase.
if phase_idx == 0:
