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Check out the documentation for more information.

State Embedding model checkpoints are meant to be used with the Arc State repository.

State is distributed via uv.

Running from pypi

uv tool install arc-state

To generate embeddings given an AnnData:

state emb --model-folder <SE-600M_MODEL_PATH> --input <INPUT_ANNDATA>.h5ad --output <OUTPUT_PATH>.h5ad

Running from source

# Clone repo
git clone github.com:arcinstitute/state
cd state

# Initialize venv
uv venv

# Install
uv tool install -e .

To generate embeddings given an AnnData:

state emb --model-folder <SE-600M_MODEL_PATH> --input <INPUT_ANNDATA>.h5ad --output <OUTPUT_PATH>.h5ad

For model licenses please see MODEL_ACCEPTABLE_USE_POLICY.md, MODEL_LICENSE.md, and LICENSE.md.

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