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Subscribe3D-MolT5: Towards Unified 3D Molecule-Text Modeling with 3D Molecular Tokenization
The integration of molecule and language has garnered increasing attention in molecular science. Recent advancements in Language Models (LMs) have demonstrated potential for the comprehensive modeling of molecule and language. However, existing works exhibit notable limitations. Most existing works overlook the modeling of 3D information, which is crucial for understanding molecular structures and also functions. While some attempts have been made to leverage external structure encoding modules to inject the 3D molecular information into LMs, there exist obvious difficulties that hinder the integration of molecular structure and language text, such as modality alignment and separate tuning. To bridge this gap, we propose 3D-MolT5, a unified framework designed to model both 1D molecular sequence and 3D molecular structure. The key innovation lies in our methodology for mapping fine-grained 3D substructure representations (based on 3D molecular fingerprints) to a specialized 3D token vocabulary for 3D-MolT5. This 3D structure token vocabulary enables the seamless combination of 1D sequence and 3D structure representations in a tokenized format, allowing 3D-MolT5 to encode molecular sequence (SELFIES), molecular structure, and text sequences within a unified architecture. Alongside, we further introduce 1D and 3D joint pre-training to enhance the model's comprehension of these diverse modalities in a joint representation space and better generalize to various tasks for our foundation model. Through instruction tuning on multiple downstream datasets, our proposed 3D-MolT5 shows superior performance than existing methods in molecular property prediction, molecule captioning, and text-based molecule generation tasks. Our code will be available on GitHub soon.
Post-pre-training for Modality Alignment in Vision-Language Foundation Models
Contrastive language image pre-training (CLIP) is an essential component of building modern vision-language foundation models. While CLIP demonstrates remarkable zero-shot performance on downstream tasks, the multi-modal feature spaces still suffer from a modality gap, which is a gap between image and text feature clusters and limits downstream task performance. Although existing works attempt to address the modality gap by modifying pre-training or fine-tuning, they struggle with heavy training costs with large datasets or degradations of zero-shot performance. This paper presents CLIP-Refine, a post-pre-training method for CLIP models at a phase between pre-training and fine-tuning. CLIP-Refine aims to align the feature space with 1 epoch training on small image-text datasets without zero-shot performance degradations. To this end, we introduce two techniques: random feature alignment (RaFA) and hybrid contrastive-distillation (HyCD). RaFA aligns the image and text features to follow a shared prior distribution by minimizing the distance to random reference vectors sampled from the prior. HyCD updates the model with hybrid soft labels generated by combining ground-truth image-text pair labels and outputs from the pre-trained CLIP model. This contributes to achieving both maintaining the past knowledge and learning new knowledge to align features. Our extensive experiments with multiple classification and retrieval tasks show that CLIP-Refine succeeds in mitigating the modality gap and improving the zero-shot performance.
CALF: Aligning LLMs for Time Series Forecasting via Cross-modal Fine-Tuning
Deep learning (e.g., Transformer) has been widely and successfully used in multivariate time series forecasting (MTSF). Unlike existing methods that focus on training models from a single modal of time series input, large language models (LLMs) based MTSF methods with cross-modal text and time series input have recently shown great superiority, especially with limited temporal data. However, current LLM-based MTSF methods usually focus on adapting and fine-tuning LLMs, while neglecting the distribution discrepancy between textual and temporal input tokens, thus leading to sub-optimal performance. To address this issue, we propose a novel Cross-Modal LLM Fine-Tuning (CALF) framework for MTSF by reducing the distribution discrepancy between textual and temporal data, which mainly consists of the temporal target branch with temporal input and the textual source branch with aligned textual input. To reduce the distribution discrepancy, we develop the cross-modal match module to first align cross-modal input distributions. Additionally, to minimize the modality distribution gap in both feature and output spaces, feature regularization loss is developed to align the intermediate features between the two branches for better weight updates, while output consistency loss is introduced to allow the output representations of both branches to correspond effectively. Thanks to the modality alignment, CALF establishes state-of-the-art performance for both long-term and short-term forecasting tasks with low computational complexity, and exhibiting favorable few-shot and zero-shot abilities similar to that in LLMs. Code is available at https://github.com/Hank0626/LLaTA.
MultiWay-Adapater: Adapting large-scale multi-modal models for scalable image-text retrieval
As the size of Large Multi-Modal Models (LMMs) increases consistently, the adaptation of these pre-trained models to specialized tasks has become a computationally and memory-intensive challenge. Traditional fine-tuning methods require isolated, exhaustive retuning for each new task, limiting the models' versatility. Moreover, current efficient adaptation techniques often overlook modality alignment, focusing only on the knowledge extraction of new tasks. To tackle these issues, we introduce Multiway-Adapter, an innovative framework incorporating an 'Alignment Enhancer' to deepen modality alignment, enabling high transferability without tuning pre-trained parameters. Our method adds fewer than 1.25\% of additional parameters to LMMs, exemplified by the BEiT-3 model in our study. This leads to superior zero-shot image-text retrieval performance compared to fully fine-tuned models, while achieving up to a 57\% reduction in fine-tuning time. Our approach offers a resource-efficient and effective adaptation pathway for LMMs, broadening their applicability. The source code is publicly available at: https://github.com/longkukuhi/MultiWay-Adapter.
GOAT-TTS: LLM-based Text-To-Speech Generation Optimized via A Dual-Branch Architecture
While large language models (LLMs) have revolutionized text-to-speech (TTS) synthesis through discrete tokenization paradigms, current architectures exhibit fundamental tensions between three critical dimensions: 1) irreversible loss of acoustic characteristics caused by quantization of speech prompts; 2) stringent dependence on precisely aligned prompt speech-text pairs that limit real-world deployment; and 3) catastrophic forgetting of the LLM's native text comprehension during optimization for speech token generation. To address these challenges, we propose an LLM-based text-to-speech Generation approach Optimized via a novel dual-branch ArchiTecture (GOAT-TTS). Our framework introduces two key innovations: (1) The modality-alignment branch combines a speech encoder and projector to capture continuous acoustic embeddings, enabling bidirectional correlation between paralinguistic features (language, timbre, emotion) and semantic text representations without transcript dependency; (2) The speech-generation branch employs modular fine-tuning on top-k layers of an LLM for speech token prediction while freezing the bottom-k layers to preserve foundational linguistic knowledge. Moreover, multi-token prediction is introduced to support real-time streaming TTS synthesis. Experimental results demonstrate that our GOAT-TTS achieves performance comparable to state-of-the-art TTS models while validating the efficacy of synthesized dialect speech data.
Uni-MoE: Scaling Unified Multimodal LLMs with Mixture of Experts
Recent advancements in Multimodal Large Language Models (MLLMs) underscore the significance of scalable models and data to boost performance, yet this often incurs substantial computational costs. Although the Mixture of Experts (MoE) architecture has been employed to efficiently scale large language and image-text models, these efforts typically involve fewer experts and limited modalities. To address this, our work presents the pioneering attempt to develop a unified MLLM with the MoE architecture, named Uni-MoE that can handle a wide array of modalities. Specifically, it features modality-specific encoders with connectors for a unified multimodal representation. We also implement a sparse MoE architecture within the LLMs to enable efficient training and inference through modality-level data parallelism and expert-level model parallelism. To enhance the multi-expert collaboration and generalization, we present a progressive training strategy: 1) Cross-modality alignment using various connectors with different cross-modality data, 2) Training modality-specific experts with cross-modality instruction data to activate experts' preferences, and 3) Tuning the Uni-MoE framework utilizing Low-Rank Adaptation (LoRA) on mixed multimodal instruction data. We evaluate the instruction-tuned Uni-MoE on a comprehensive set of multimodal datasets. The extensive experimental results demonstrate Uni-MoE's principal advantage of significantly reducing performance bias in handling mixed multimodal datasets, alongside improved multi-expert collaboration and generalization. Our findings highlight the substantial potential of MoE frameworks in advancing MLLMs and the code is available at https://github.com/HITsz-TMG/UMOE-Scaling-Unified-Multimodal-LLMs.
SSR: Alignment-Aware Modality Connector for Speech Language Models
Fusing speech into pre-trained language model (SpeechLM) usually suffers from inefficient encoding of long-form speech and catastrophic forgetting of pre-trained text modality. We propose SSR-Connector (Segmented Speech Representation Connector) for better modality fusion. Leveraging speech-text alignments, our approach segments and compresses speech features to match the granularity of text embeddings. Additionally, we introduce a two-stage training pipeline that includes the distillation and fine-tuning phases to mitigate catastrophic forgetting. SSR-Connector outperforms existing mechanism for speech-text modality fusion, consistently achieving better speech understanding (e.g., +10 accuracy on StoryCloze and +20 on Speech-MMLU) while preserving pre-trained text ability.
ImageBind-LLM: Multi-modality Instruction Tuning
We present ImageBind-LLM, a multi-modality instruction tuning method of large language models (LLMs) via ImageBind. Existing works mainly focus on language and image instruction tuning, different from which, our ImageBind-LLM can respond to multi-modality conditions, including audio, 3D point clouds, video, and their embedding-space arithmetic by only image-text alignment training. During training, we adopt a learnable bind network to align the embedding space between LLaMA and ImageBind's image encoder. Then, the image features transformed by the bind network are added to word tokens of all layers in LLaMA, which progressively injects visual instructions via an attention-free and zero-initialized gating mechanism. Aided by the joint embedding of ImageBind, the simple image-text training enables our model to exhibit superior multi-modality instruction-following capabilities. During inference, the multi-modality inputs are fed into the corresponding ImageBind encoders, and processed by a proposed visual cache model for further cross-modal embedding enhancement. The training-free cache model retrieves from three million image features extracted by ImageBind, which effectively mitigates the training-inference modality discrepancy. Notably, with our approach, ImageBind-LLM can respond to instructions of diverse modalities and demonstrate significant language generation quality. Code is released at https://github.com/OpenGVLab/LLaMA-Adapter.
Deciphering Cross-Modal Alignment in Large Vision-Language Models with Modality Integration Rate
We present the Modality Integration Rate (MIR), an effective, robust, and generalized metric to indicate the multi-modal pre-training quality of Large Vision Language Models (LVLMs). Large-scale pre-training plays a critical role in building capable LVLMs, while evaluating its training quality without the costly supervised fine-tuning stage is under-explored. Loss, perplexity, and in-context evaluation results are commonly used pre-training metrics for Large Language Models (LLMs), while we observed that these metrics are less indicative when aligning a well-trained LLM with a new modality. Due to the lack of proper metrics, the research of LVLMs in the critical pre-training stage is hindered greatly, including the training data choice, efficient module design, etc. In this paper, we propose evaluating the pre-training quality from the inter-modal distribution distance perspective and present MIR, the Modality Integration Rate, which is 1) Effective to represent the pre-training quality and show a positive relation with the benchmark performance after supervised fine-tuning. 2) Robust toward different training/evaluation data. 3) Generalize across training configurations and architecture choices. We conduct a series of pre-training experiments to explore the effectiveness of MIR and observe satisfactory results that MIR is indicative about training data selection, training strategy schedule, and model architecture design to get better pre-training results. We hope MIR could be a helpful metric for building capable LVLMs and inspire the following research about modality alignment in different areas. Our code is at: https://github.com/shikiw/Modality-Integration-Rate.
S2ST-Omni: An Efficient Multilingual Speech-to-Speech Translation Framework via Seamless Speech-Text Alignment and Progressive Fine-tuning
Despite recent advances in multilingual speech-to-speech translation (S2ST), several critical challenges persist: 1) achieving high-quality translation remains a major hurdle, and 2) most existing methods heavily rely on large-scale parallel speech corpora, which are costly and difficult to obtain. To address these issues, we propose S2ST-Omni, an efficient and scalable framework for multilingual S2ST. Specifically, we decompose the S2ST task into speech-to-text translation (S2TT) and text-to-speech synthesis (TTS). For S2TT, we propose an effective speech language model that integrates the pretrained Whisper encoder for robust audio understanding and Qwen 3.0 for advanced text comprehension. A lightweight speech adapter is employed to bridge the modality gap between speech and text representations. To further facilitate the multimodal knowledge learning, a two-stage fine-tuning strategy is introduced. In the TTS stage, we adopt a streaming autoregressive generation approach to produce natural and fluent target speech. Experiments on the CVSS benchmark show that S2ST-Omni consistently outperforms existing state-of-the-art S2ST systems in translation quality, highlighting its effectiveness and superiority.
Distribution-Aware Prompt Tuning for Vision-Language Models
Pre-trained vision-language models (VLMs) have shown impressive performance on various downstream tasks by utilizing knowledge learned from large data. In general, the performance of VLMs on target tasks can be further improved by prompt tuning, which adds context to the input image or text. By leveraging data from target tasks, various prompt-tuning methods have been studied in the literature. A key to prompt tuning is the feature space alignment between two modalities via learnable vectors with model parameters fixed. We observed that the alignment becomes more effective when embeddings of each modality are `well-arranged' in the latent space. Inspired by this observation, we proposed distribution-aware prompt tuning (DAPT) for vision-language models, which is simple yet effective. Specifically, the prompts are learned by maximizing inter-dispersion, the distance between classes, as well as minimizing the intra-dispersion measured by the distance between embeddings from the same class. Our extensive experiments on 11 benchmark datasets demonstrate that our method significantly improves generalizability. The code is available at https://github.com/mlvlab/DAPT.
3DMIT: 3D Multi-modal Instruction Tuning for Scene Understanding
The remarkable potential of multi-modal large language models (MLLMs) in comprehending both vision and language information has been widely acknowledged. However, the scarcity of 3D scenes-language pairs in comparison to their 2D counterparts, coupled with the inadequacy of existing approaches in understanding of 3D scenes by LLMs, poses a significant challenge. In response, we collect and construct an extensive dataset comprising 75K instruction-response pairs tailored for 3D scenes. This dataset addresses tasks related to 3D VQA, 3D grounding, and 3D conversation. To further enhance the integration of 3D spatial information into LLMs, we introduce a novel and efficient prompt tuning paradigm, 3DMIT. This paradigm eliminates the alignment stage between 3D scenes and language and extends the instruction prompt with the 3D modality information including the entire scene and segmented objects. We evaluate the effectiveness of our method across diverse tasks in the 3D scene domain and find that our approach serves as a strategic means to enrich LLMs' comprehension of the 3D world. Our code is available at https://github.com/staymylove/3DMIT.
OneEncoder: A Lightweight Framework for Progressive Alignment of Modalities
Cross-modal alignment Learning integrates information from different modalities like text, image, audio and video to create unified models. This approach develops shared representations and learns correlations between modalities, enabling applications such as visual question answering and audiovisual content analysis. Current techniques rely on large modality-specific encoders, necessitating fine-tuning or training from scratch on vast aligned datasets (e.g., text-image, text-audio, image-audio). This approach has limitations: (i) it is very expensive due to the need for training large encoders on extensive datasets, (ii) acquiring aligned large paired datasets is challenging, and (iii) adding new modalities requires retraining the entire framework to incorporate these modalities. To address these issues, we propose OneEncoder, a lightweight framework that progressively represents and aligns four modalities (image, text, audio, video). Initially, we train a lightweight Universal Projection module (UP) to align image and text modalities. Then, we freeze the pretrained UP and progressively align future modalities to those already aligned. OneEncoder operates efficiently and cost-effectively, even in scenarios where vast aligned datasets are unavailable, due to its lightweight design. Trained on small paired datasets, it shows strong performance in tasks like classification, querying, and visual question answering, surpassing methods that rely on large datasets and specialized encoders.
MM-Lego: Modular Biomedical Multimodal Models with Minimal Fine-Tuning
Learning holistic computational representations in physical, chemical or biological systems requires the ability to process information from different distributions and modalities within the same model. Thus, the demand for multimodal machine learning models has sharply risen for modalities that go beyond vision and language, such as sequences, graphs, time series, or tabular data. While there are many available multimodal fusion and alignment approaches, most of them require end-to-end training, scale quadratically with the number of modalities, cannot handle cases of high modality imbalance in the training set, or are highly topology-specific, making them too restrictive for many biomedical learning tasks. This paper presents Multimodal Lego (MM-Lego), a modular and general-purpose fusion and model merging framework to turn any set of encoders into a competitive multimodal model with no or minimal fine-tuning. We achieve this by introducing a wrapper for unimodal encoders that enforces lightweight dimensionality assumptions between modalities and harmonises their representations by learning features in the frequency domain to enable model merging with little signal interference. We show that MM-Lego 1) can be used as a model merging method which achieves competitive performance with end-to-end fusion models without any fine-tuning, 2) can operate on any unimodal encoder, and 3) is a model fusion method that, with minimal fine-tuning, achieves state-of-the-art results on six benchmarked multimodal biomedical tasks.
From Specific-MLLM to Omni-MLLM: A Survey about the MLLMs alligned with Multi-Modality
From the Specific-MLLM, which excels in single-modal tasks, to the Omni-MLLM, which extends the range of general modalities, this evolution aims to achieve understanding and generation of multimodal information. Omni-MLLM treats the features of different modalities as different "foreign languages," enabling cross-modal interaction and understanding within a unified space. To promote the advancement of related research, we have compiled 47 relevant papers to provide the community with a comprehensive introduction to Omni-MLLM. We first explain the four core components of Omni-MLLM for unified modeling and interaction of multiple modalities. Next, we introduce the effective integration achieved through "alignment pretraining" and "instruction fine-tuning," and discuss open-source datasets and testing of interaction capabilities. Finally, we summarize the main challenges facing current Omni-MLLM and outline future directions.
RAVEN: Query-Guided Representation Alignment for Question Answering over Audio, Video, Embedded Sensors, and Natural Language
Multimodal question answering (QA) often requires identifying which video, audio, or sensor tokens are relevant to the question. Yet modality disagreements are common: off-camera speech, background noise, or motion outside the field of view often mislead fusion models that weight all streams equally. We present RAVEN, a unified QA architecture whose core is QuART, a query-conditioned cross-modal gating module that assigns scalar relevance scores to each token across modalities, enabling the model to amplify informative signals and suppress distractors before fusion. RAVEN is trained through a three-stage pipeline comprising unimodal pretraining, query-aligned fusion, and disagreement-oriented fine-tuning -- each stage targeting a distinct challenge in multi-modal reasoning: representation quality, cross-modal relevance, and robustness to modality mismatch. To support training and evaluation, we release AVS-QA, a dataset of 300K synchronized Audio--Video-Sensor streams paired with automatically generated question-answer pairs. Experimental results on seven multi-modal QA benchmarks -- including egocentric and exocentric tasks -- show that RAVEN achieves up to 14.5\% and 8.0\% gains in accuracy compared to state-of-the-art multi-modal large language models, respectively. Incorporating sensor data provides an additional 16.4\% boost, and the model remains robust under modality corruption, outperforming SOTA baselines by 50.23\%. Our code and dataset are available at https://github.com/BASHLab/RAVEN.
MoCa: Modality-aware Continual Pre-training Makes Better Bidirectional Multimodal Embeddings
Multimodal embedding models, built upon causal Vision Language Models (VLMs), have shown promise in various tasks. However, current approaches face three key limitations: the use of causal attention in VLM backbones is suboptimal for embedding tasks; scalability issues due to reliance on high-quality labeled paired data for contrastive learning; and limited diversity in training objectives and data. To address these issues, we propose MoCa, a two-stage framework for transforming pre-trained VLMs into effective bidirectional multimodal embedding models. The first stage, Modality-aware Continual Pre-training, introduces a joint reconstruction objective that simultaneously denoises interleaved text and image inputs, enhancing bidirectional context-aware reasoning. The second stage, Heterogeneous Contrastive Fine-tuning, leverages diverse, semantically rich multimodal data beyond simple image-caption pairs to enhance generalization and alignment. Our method addresses the stated limitations by introducing bidirectional attention through continual pre-training, scaling effectively with massive unlabeled datasets via joint reconstruction objectives, and utilizing diverse multimodal data for enhanced representation robustness. Experiments demonstrate that MoCa consistently improves performance across MMEB and ViDoRe-v2 benchmarks, achieving new state-of-the-art results, and exhibits strong scalability with both model size and training data on MMEB.
Turing Representational Similarity Analysis (RSA): A Flexible Method for Measuring Alignment Between Human and Artificial Intelligence
As we consider entrusting Large Language Models (LLMs) with key societal and decision-making roles, measuring their alignment with human cognition becomes critical. This requires methods that can assess how these systems represent information and facilitate comparisons to human understanding across diverse tasks. To meet this need, we developed Turing Representational Similarity Analysis (RSA), a method that uses pairwise similarity ratings to quantify alignment between AIs and humans. We tested this approach on semantic alignment across text and image modalities, measuring how different Large Language and Vision Language Model (LLM and VLM) similarity judgments aligned with human responses at both group and individual levels. GPT-4o showed the strongest alignment with human performance among the models we tested, particularly when leveraging its text processing capabilities rather than image processing, regardless of the input modality. However, no model we studied adequately captured the inter-individual variability observed among human participants. This method helped uncover certain hyperparameters and prompts that could steer model behavior to have more or less human-like qualities at an inter-individual or group level. Turing RSA enables the efficient and flexible quantification of human-AI alignment and complements existing accuracy-based benchmark tasks. We demonstrate its utility across multiple modalities (words, sentences, images) for understanding how LLMs encode knowledge and for examining representational alignment with human cognition.
